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Related Concept Videos

Homeostatic Imbalance01:10

Homeostatic Imbalance

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Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
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What is Homeostasis?01:16

What is Homeostasis?

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Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

20.2K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
20.2K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
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Counteracting health risks by Modulating Homeostatic Signaling.

Junqiang J Tian1, Mark Levy1, Xuekai Zhang2

  • 1USANA Health Science, Inc., 3838 Parkway Blvd, Salt Lake City, UT 84121, USA.

Pharmacological Research
|June 6, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a novel prophylactic intervention strategy that modulates homeostatic signaling to prevent disease. By mimicking stress responses or downregulating them, this approach offers preemptive health risk countermeasures.

Keywords:
AdaptogenHomeostasisHormesisModulant of Homeostatic SignalingTCM Tonics

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Area of Science:

  • Physiology
  • Cellular Biology
  • Pharmacology

Background:

  • Homeostasis, the maintenance of stable physiological parameters, is crucial for adaptation to stressors.
  • Cellular homeostasis is regulated by signaling pathways, with disruptions risking collateral damage under chronic stress.
  • Existing interventions like adaptogens and hormesis aim to manage stress responses.

Purpose of the Study:

  • To define and characterize a new modality of prophylactic intervention targeting homeostatic signaling.
  • To differentiate this novel approach from existing homeostasis-related interventions.
  • To provide literature-based evidence supporting the concept of preemptive disease prevention via homeostatic modulation.

Main Methods:

  • Literature review and conceptual analysis.
  • Characterization of stressor-mimicking and downregulating medicinal strategies.
  • Comparison with adaptogen, hormesis, and xenohormesis concepts.

Main Results:

  • Homeostatic signaling can be modulated for preemptive disease prevention.
  • Stressor-mimicking medicinals can elicit adaptive responses as countermeasures.
  • Downregulating medicinals can suppress harmful responses to prevent pathogenesis.

Conclusions:

  • A novel prophylactic intervention modality based on modulating homeostatic signaling is proposed.
  • This approach offers preemptive health risk countermeasures for individuals with specific risk factors.
  • The strategy aims to forestall diseases by intervening in homeostatic mechanisms before adverse events occur.