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25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people
Nathalia Fidelis Lins Vieira1, Carlos Queiroz do Nascimento2, Janaina da Silva Nascimento3
1Institute of Biological Sciences, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
Purpose:
The objective of this study was to identify an association between serum levels of 25(OH) D, inflammation and cardiovascular disease risk in older adults.
Methods:
This was a cross-sectional study, with older adults of both sexes, investigating variables on lifestyle, anthropometric assessments (weight, height, waist circumference, BMI), and systemic arterial hypertension (systolic blood pressure, SBP, and diastolic blood pressure DBP), serum levels of 25(OH)D, serum high-sensitive C-reactive protein (hs-CRP), serum lipid profile and fasting blood glucose. Cardiovascular disease risk was assessed using the global risk score for cardiovascular events, the Framingham criteria.
Results:
The sample consisted of 124 participants, 50.8% of whom were at high risk for cardiovascular events. Older adults with 25(OH)D insufficiency presented higher levels of blood sugar (p < 0.01), LDL-c (p = 0.03) SBP (p < 0.01) and hs-CRP (p < 0.01). When grouped by serum concentrations hs-CRP, it was observed that higher hs-CRP levels were associated with higher blood glucose (p = 0.02), SBP (p = 0.04) and lower HDL-c concentrations (p = 0.02). It was also observed that 25(OH)D insufficiency increased the chance of a high risk for cardiovascular events by 2.8 times (OR = 2.80; p = 0.01), which with high hs-CRP concentrations increased to 4.75 times (OR = 4.75; p < 0.01).
Conclusion:
Low concentrations of 25(OH)D and the presence of inflammation in older adults are associated with a high risk for cardiovascular diseases.
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