Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

7.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
7.2K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

13.5K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
13.5K
RNA Stability01:53

RNA Stability

34.0K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
34.0K
Nucleic acids02:43

Nucleic acids

170.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
170.8K
Nucleic Acids02:43

Nucleic Acids

46.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
46.0K
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

24.8K
RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
24.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravenous transplantation of mesenchymal stem cells improves cardiac performance after acute myocardial ischemia in female rats.

Transplant international : official journal of the European Society for Organ Transplantation·2006
Same author

[Effects of mechanical tensile stress on the expression of ICAM-1 mRNA in osteoblasts differentiated from rBMSCs].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·2006
Same author

[Effects of osteoporosis on experimental tooth movement in aged rats].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·2006
Same author

MCALIGN2: faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution.

BMC bioinformatics·2006
Same author

[Managements of masked mastoiditis].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2006
Same author

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

The Journal of biological chemistry·2006

Related Experiment Video

Updated: Sep 20, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

4.5K

3dRNA: 3D Structure Prediction from Linear to Circular RNAs.

Yi Zhang1, Jun Wang1, Yi Xiao1

  • 1Institute of Biophysics, School of Physics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.

Journal of Molecular Biology
|June 6, 2022
PubMed
Summary
This summary is machine-generated.

The 3dRNA computational method predicts RNA 3D structures, now extended to circular RNAs. Predicted circular RNA structures are more stable when binding ligands than linear RNA counterparts.

Keywords:
RNA 3D structure predictioncircular RNAlinear RNA

More Related Videos

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.7K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.7K

Related Experiment Videos

Last Updated: Sep 20, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

4.5K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.7K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.7K

Area of Science:

  • Computational Biology
  • Structural Biology
  • Bioinformatics

Background:

  • Experimental determination of RNA 3D structures is limited.
  • Computational methods are crucial for predicting RNA 3D structures.
  • The 3dRNA tool offers automated, template-based RNA 3D structure prediction.

Purpose of the Study:

  • To extend the 3dRNA method for predicting 3D structures of circular RNAs.
  • To analyze the structural differences between circular and linear RNAs.
  • To investigate the ligand-binding stability of predicted circular RNA structures.

Main Methods:

  • Utilized the automated template-based 3dRNA method.
  • Incorporated secondary structure elements (SSEs) for structure prediction.
  • Treated pseudoknot base pairings as restraints.
  • Extended the method to accommodate circular RNA specificities.

Main Results:

  • Circular RNAs were classified into four types based on their 3D structures.
  • Two circular RNA types exhibited similar 3D structures to their linear counterparts.
  • Two circular RNA types displayed distinct 3D structures compared to linear RNAs.
  • Predicted circular RNA structures showed enhanced ligand-binding stability.

Conclusions:

  • The 3dRNA tool is successfully extended to predict circular RNA 3D structures.
  • Structural diversity exists among different types of circular RNAs.
  • Circular RNAs may offer advantages in ligand binding stability compared to linear RNAs.