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Low-dose mesenchymal stem cell therapy for discogenic pain: safety and efficacy results from a 1-year feasibility
Dan Bates1,2,3,4, David Vivian1,2,3,4, Julien Freitag1,2,5
1Melbourne Stem Cell Centre, Box Hill, Victoria, 3128, Australia.
Aim:
To evaluate safety and efficacy of low dose autologous adipose-derived mesenchymal stem cells (ADMSCs) for treatment of disc degeneration resulting in low back pain (LBP).
Methods:
Nine participants with chronic LBP originating from single-level lumbar disc disease underwent intradiscal injection of 10 million ADMSCs with optional repetition after 6 months.
Results:
No unexpected or serious adverse events were recorded. Seven (78%) of participants reported reductions in pain 12 months after treatment. Five (56%) reported increased work capacity. Three (33%) reduced analgesic medication. Improvements in EQ-5D and Oswestry disability index results were observed. MRI demonstrated no further disc degeneration and improvements to annular fissures and disc protrusions.
Conclusion:
This study provides initial evidence of safety and efficacy of ADMSCs for discogenic LBP.
