Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

224
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
224
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

137
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
137

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suvorexant protects from ocular complications of diabetes in db/db mice.

BMJ open diabetes research & care·2026
Same author

Bmal1 overexpression in suprachiasmatic nucleus protects from retinal neurovascular deficits in a mouse model of diabetes.

Diabetologia·2026
Same author

Sedimentation velocity analytical ultracentrifugation (SV-AUC) for adeno-associated virus characterization: impact of cell alignment.

European biophysics journal : EBJ·2026
Same author

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease.

Glia·2026
Same author

High-fat Western diet induces retinal and metabolic alterations in APOE3 and APOE4 knock-in mice.

Scientific reports·2026
Same author

Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa.

Investigative ophthalmology & visual science·2025
Same journal

Essential Role for Telomeric Repeat-Binding Factor 2 in Cardiac Development and Function.

FASEB bioAdvances·2026
Same journal

Investigation of Spexin Effects on Insulin-Dependent Pathway Genes in High-Glucose-Induced Insulin-Resistant C2C12 Myotubes.

FASEB bioAdvances·2026
Same journal

Correction to "MicroRNA 15a and 16 Regulate Proteostasis in Non-Small Cell Lung Cancer".

FASEB bioAdvances·2026
Same journal

Prediction of Risk of Unplanned Readmission or Death in Elderly Heart Failure Patients During the Vulnerable Phase: Machine Learning With SHAP Interpretation.

FASEB bioAdvances·2026
Same journal

Comparative Effects of Cigarette and Hookah Smoking on Oral Microbiota Composition and Blood Indices in Young Adult Males.

FASEB bioAdvances·2026
Same journal

Lanthanum Chloride in Vascular Calcification: Effects on Nano-Hydroxyapatite and PPARγ/Wnt/β-Catenin.

FASEB bioAdvances·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

4.5K

Circadian rhythm disruption results in visual dysfunction.

Deepa Mathew1, Qianyi Luo1, Ashay D Bhatwadekar1

  • 1Department of Ophthalmology Indiana University Indianapolis Indiana USA.

FASEB Bioadvances
|June 6, 2022
PubMed
Summary
This summary is machine-generated.

Circadian rhythm disruption from artificial light impacts vision. Mice exposed to disrupted light cycles showed reduced visual acuity and retinal changes, with distinct effects based on their entrainment behavior.

Keywords:
biological clockcircadian rhythm disruptionentrainmentretinavision

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K
Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

577

Related Experiment Videos

Last Updated: Sep 20, 2025

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

4.5K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K
Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

577

Area of Science:

  • Ophthalmology
  • Chronobiology
  • Neuroscience

Background:

  • Artificial light exposure and 24/7 work disrupt the biological clock, leading to circadian rhythm disruption (CRD).
  • CRD is linked to metabolic and neurodegenerative diseases, but its impact on vision remains unclear.
  • The retina has an autonomous clock that responds to light cues.

Purpose of the Study:

  • To investigate the effects of CRD on retinal morphology, physiology, and vision in mice.
  • To explore how different light-entrainment behaviors under CRD influence visual function and retinal health.

Main Methods:

  • Mice were housed in a disrupted light/dark cycle (L10:D10) to induce CRD.
  • Assessed visual acuity, retinal structure, photoreceptor count, and electroretinogram (ERG) responses.
  • Analyzed retinal proteome and oxidative stress-antioxidant mechanisms across different entrainment behaviors.

Main Results:

  • Mice exhibited three entrainment behaviors: 'entrained,' 'free-running,' and 'zigzagging.'
  • All CRD groups showed reduced visual acuity, retinal thinning, and fewer photoreceptors.
  • ERG response reduction was specific to the 'entrained' group; proteomic analysis revealed distinct changes and impaired oxidative stress-antioxidant balance across behaviors.

Conclusions:

  • CRD significantly alters entrainment behavior and leads to visual dysfunction in mice.
  • Entrainment behavior critically influences retinal physiology and visual outcomes under CRD.
  • Findings highlight the role of CRD in visual impairment and suggest implications for retinal disease etiology.