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Updated: Sep 20, 2025
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
COVID-19 and Intestinal Ischemia: A Multicenter Case Series
Maryam Sarkardeh1,2, Elahe Meftah3, Narjes Mohammadzadeh4
1Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
COVID-19 can lead to severe gastrointestinal issues like bowel necrosis, with a high mortality rate. This case series highlights the critical link between COVID-19 and intestinal ischemia, emphasizing the need for further investigation.
Area of Science:
- Gastroenterology and Infectious Diseases
- Surgical Pathology
- Critical Care Medicine
Background:
- Gastrointestinal symptoms are frequent in COVID-19 patients, but severe complications like intestinal ischemia are rare.
- This case series investigates the clinical presentation and outcomes of patients with concurrent COVID-19 and intestinal ischemia.
Observation:
- The study included 24 adult patients with COVID-19 and intestinal ischemia, with a median age of 61.5 years.
- Gastrointestinal symptoms, primarily abdominal pain, appeared a median of seven days post-COVID-19 diagnosis.
- Elevated C-Reactive Protein and D-dimer levels were observed in patients prior to surgery.
Findings:
- Bowel necrosis was present in 15 (62.5%) of the patients, leading to a high mortality rate.
- Pathologic evaluation revealed general features of intestinal necrosis, with specific cases of mucormycosis and vasculitis.
- The median hospital stay for patients with bowel necrosis was 6.5 days.
Implications:
- Intestinal ischemia in COVID-19 patients carries a significant mortality risk.
- Further research is crucial to understand the pathophysiology and management of COVID-19-associated intestinal ischemia.
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