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[Intestinal lesions in acute respiratory viral and mycoplasma infections]
Abstract:
Histologic study using semiquantitative analysis and immunofluorescent microscopy of the intestine performed on 278 children of different age who died of acute respiratory, viral and Mycoplasma infections revealed intestinal changes in 168 cases. The incidence and degree of these changes depended on the duration of the disease and the type of the intensive therapy used. Beginning from day 2 of the disease specific changes in the enterocytes in the form of giant-cell metamorphosis were noted. These changes gradually increased reaching their maximum on day 7-9 when in all cases of acute viral respiratory infections microlysis of enterocytes was observed. It was maximal on day 5-6 and inhibited under the influence of intensive therapy. In addition some nonspecific changes were present: circulatory disorders and cellular reaction of the stroma, that changed depending on the duration of the disease being probably a manifestation of a local immune reaction.
Insights
Intestinal changes, including giant-cell metamorphosis and enterocyte microlysis, were observed in children with acute respiratory infections. Intensive therapy impacted the severity and duration of these viral-induced intestinal alterations.
Area of Science:
- Pediatric Pathology
- Infectious Diseases
- Gastroenterology
Background:
- Acute respiratory infections can impact multiple organ systems.
- Intestinal involvement in pediatric viral infections requires further investigation.
- Understanding histologic changes is crucial for disease management.
Purpose of the Study:
- To investigate intestinal histologic changes in children with acute respiratory infections.
- To correlate these changes with disease duration and treatment.
- To identify specific viral-induced enterocyte alterations.
Main Methods:
- Histologic examination using semiquantitative analysis.
- Immunofluorescent microscopy of intestinal tissue.
- Study included 278 children with fatal acute respiratory, viral, and Mycoplasma infections.
Main Results:
- Intestinal changes were found in 168 out of 278 children.
- Specific changes included giant-cell metamorphosis of enterocytes from day 2.
- Enterocyte microlysis peaked on days 5-6 in viral infections and was reduced by intensive therapy.
Conclusions:
- Acute viral respiratory infections induce significant intestinal changes in children.
- Disease duration and intensive therapy influence the severity of these changes.
- Nonspecific changes suggest a local immune response within the intestine.