[Morphological changes in the internal organs in experimental staphylococcal sepsis]

In 200 albino rats pathomorphological changes of different organs were studied during experimental staphylococcal sepsis (from 3 to 45 days of the disease), caused by intramuscular injection of 0.15-0.20 ml suspension of microbes (10(15) per ml) in 10% CaCl2 solution. Local piemic focus occurred first, followed by bacteremia and generalized sepsis manifest with secondary piemic foci in the viscera. In the cytologic imprints early stages of piemic metastatic focus formation in liver, kidneys and other organs were demonstrated. Microcirculatory, dystrophic changes, as well as lymphoid system suppression were revealed. The authors come to the conclusion that all the signs are similar to general morphologic criteria of sepsis in humans.