Primary ewing sarcoma in the uterine cervix with multiple bone metastases

Area of Science:

• Oncology
• Pathology
• Genetics

Background:

• Cervical masses can present asymptomatically.
• Ewing sarcoma is a rare malignant tumor typically affecting bone and soft tissues.
• Human papillomavirus (HPV) is a known risk factor for cervical cancer.

Observation:

• A 45-year-old female with HPV-52 infection and prior thyroid cancer treatment presented with an asymptomatic cervical mass.
• MRI revealed a large cervical mass with local invasion and bone lesions.
• Histopathology and genetic testing confirmed Ewing sarcoma.

Findings:

• The patient experienced sudden paraplegia due to spinal metastasis.
• PET/CT showed widespread bone metastases.
• Despite treatment, the patient's condition rapidly declined, leading to death within three months.

Implications:

• This case underscores the potential for Ewing sarcoma to arise in the cervix.
• It highlights the aggressive behavior and rapid metastatic potential of cervical Ewing sarcoma.
• The case emphasizes the need for early diagnosis and aggressive treatment strategies for rare gynecologic malignancies.