[Vasoconstrictor effects on isolated vessel segments determined by pressure-volume measurements]

A method for pressure-volume measurement in isolated segments of dog saphenous veins and femoral arteries is described. Its applicability was shown by means of the vasoconstrictor effects of noradrenaline and serotonin. By this method changes in intravascular pressure were measured in dependence upon the in- and outflowing volume of liquid. The pressure-volume diagrams allowed to estimate the intravascular pressure, work, resistance and compliance of the vascular segments. From the diagrams differences in the responses of veins and arteries to the biogenic amines could be demonstrated. The concentration-response relationships of the venous segments for noradrenaline and serotonin corresponded to those obtained in helically cut venous strips.