Cyclodextrin metal-organic frameworks and derivatives: recent developments and applications

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Metal-organic frameworks (MOFs) are extensively researched for gas storage, catalysis, and energy applications.
• Developing biocompatible MOFs presents significant challenges, limiting their clinical and biological applications.
• Cyclodextrins (CDs), cyclic oligosaccharides, are ideal biocompatible linkers for MOF synthesis, offering unique host-guest properties.

Purpose of the Study:

• To provide a comprehensive overview of cyclodextrin-based MOFs (CD-MOFs).
• To discuss the synthesis, design, properties, and applications of CD-MOFs.
• To highlight the potential and future directions of CD-MOF materials.

Main Methods:

• Review of existing literature on CD-MOF synthesis and characterization.
• Categorization of CD-MOF materials into three classes: CD-MOFs, CD-MOF hybrids, and CD-MOF-derived materials.
• Analysis of CD-MOF applications across various fields.

Main Results:

• CD-MOFs leverage the inherent properties of CDs, including host-guest complexation, high encapsulation capacity, and hydrophilicity.
• CD-MOFs can be synthesized using biocompatible linkers and metal ions, overcoming previous limitations.
• Three distinct categories of CD-MOF materials have been identified and reviewed.

Conclusions:

• CD-MOFs represent a promising class of materials with enhanced biocompatibility and functionality.
• Their unique properties enable novel applications in drug delivery, cancer therapy, sensing, separations, and more.
• Further research and development in CD-MOF design and fabrication hold significant potential for future advancements.