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Updated: Sep 20, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Recent advances in the treatment of advanced prostate cancer: maximizing existing therapies while searching for novel

Theodore Gourdin1

  • 1Division of Hematology Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Current Opinion in Oncology
|June 7, 2022
PubMed
Abstract

Insights

Combining therapies like androgen deprivation and docetaxel shows promise for metastatic prostate cancer. Novel radiopharmaceuticals are also emerging for advanced castration-resistant prostate cancer treatment.

Area of Science:

  • Oncology
  • Urology

Background:

  • Advanced prostate cancer treatment is evolving rapidly.
  • New therapeutic strategies are under investigation.

Purpose of the Study:

  • To review recent research on advanced prostate cancer treatments.
  • To highlight emerging therapeutic combinations and agents.

Main Methods:

  • Review of recent clinical trial data.
  • Analysis of emerging treatment strategies for prostate cancer.

Main Results:

  • Combining androgen deprivation, docetaxel, and androgen-receptor-targeted therapies may improve outcomes in treatment-naïve metastatic prostate cancer.
  • Genomically targeted therapies and radiopharmaceuticals are being evaluated for advanced castration-resistant prostate cancer.

Conclusions:

  • Evidence supports earlier use of available therapies in advanced prostate cancer.
  • Novel radiopharmaceuticals are anticipated for castration-resistant disease treatment.

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