Increased airway resistance can be related to the decrease in the functional capacity in obese women.
Larissa Perossi1, Mayara Holtz1, Daniele Oliveira Dos Santos1
1Health Sciences Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Plos One
|June 7, 2022
Summary
Obesity increases airway resistance, impacting walking capacity in women. Impulse oscillometry system (IOS) detected this obstruction, correlating with reduced six-minute walk test (6MWT) distance, suggesting peripheral airway resistance worsens functional ability.
Area of Science:
- Pulmonary Medicine
- Obesity Research
- Respiratory Physiology
Background:
- Obesity is linked to increased airway resistance, particularly in peripheral airways.
- This can lead to dyspnea and reduced functional capacity.
- Understanding this relationship is crucial for managing obesity-related respiratory issues.
Purpose of the Study:
- To investigate the relationship between airway resistance and walking capacity in women with morbid obesity.
- To determine if impulse oscillometry system (IOS) can identify airway changes in this population.
- To correlate IOS findings with the six-minute walk test (6MWT) results.
Main Methods:
- Thirty-seven women with grade III obesity underwent spirometry, IOS, and 6MWT.
- Daily dyspnea perception and physical activity levels were also assessed.
- IOS was used to measure central and peripheral airway resistance.
Main Results:
- Spirometry did not reveal significant ventilator disorders.
- IOS identified increased central and peripheral airway resistance compared to predicted values.
- A significant negative correlation was found between airway resistance parameters (R5, R5-20) and 6MWT distance, and a positive correlation with X5.
Conclusions:
- Impulse oscillometry system (IOS) can detect airway obstruction in severe obesity, even with normal spirometry.
- Increased peripheral airway resistance, identified by IOS, is associated with reduced walking capacity in women with morbid obesity.
- IOS is a valuable tool for assessing respiratory function and its impact on functional capacity in obese individuals.
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