Related Experiment Video
Updated: Sep 20, 2025
07:33
A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Published on: May 21, 2010
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A step forward for stress-induced ataxia
Hugo G Marques1, Pedro L Castelhanito1, Megan R Carey1
1Neuroscience Program, Champalimaud Center for the Unknown, Lisbon, Portugal.
Trends in Neurosciences
|June 7, 2022
Abstract:
Patients with episodic ataxia type 2 (EA2) display attacks of severe incoordination and dystonia that can be triggered by stress. In a recent study, Snell, Vitenzon, Tara, and colleagues found a mechanistic pathway by which norepinephrine (NE) alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2 and identified a pharmacological intervention that effectively reduces them.
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