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Related Experiment Videos

[Blood phospholipases in burn shock].

T L Zaets, V K Sologub, V I Nikulin

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |April 1, 1987
    PubMed
    Summary

    Plasma phospholipase A and C activity increases rapidly after severe burns, intensifying lipid peroxidation. This suggests enzymes released from damaged tissues are activated by free radicals during burn shock.

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    Area of Science:

    • Biochemistry
    • Physiology
    • Burn Medicine

    Background:

    • Severe burns (affecting >20% body surface) induce a shock state.
    • Plasma phospholipase A and C are key enzymes in lipid metabolism.

    Purpose of the Study:

    • To investigate the activity of plasma phospholipases A and C during burn shock.
    • To explore the relationship between phospholipase activity and lipid peroxidation post-burn.

    Main Methods:

    • Monitoring plasma phospholipase A and C activity in patients with severe burns.
    • Assessing lipid peroxidation levels concurrently with enzyme activity measurements.

    Main Results:

    • Plasma phospholipase A and C activity was detected during burn shock.
    • Enzyme activity increased significantly within 30 minutes post-burning.
    • A simultaneous intensification of lipid peroxidation was observed.

    Conclusions:

    • Phospholipase A and C activation is an early event in severe burn injury.
    • Free-radical products likely activate phospholipases released from damaged tissues.
    • These enzymatic changes contribute to the pathophysiology of burn shock.

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