Related Experiment Video
Updated: Sep 20, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
Targeting cellular senescence to combat cancer and ageing
Chen Wang1, Xue Hao1, Rugang Zhang1
1Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Abstract:
Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro-inflammatory factors, chemokines and growth factors. In this review, we summarize the context-dependent role of cellular senescence in ageing and in age-related diseases, such as cancer. We discuss current approaches to targeting senescence to develop therapeutic strategies to combat cancer and to promote healthy ageing, and we outline our vision for future research directions for senescence-based interventions in these fields.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Telomeres and Telomerase
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Mitochondria
PI3K/mTOR/AKT Signaling Pathway

