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MIR4435-2HG: A Tumor-associated Long Non-coding RNA.
Fangnan Zhao1,2, Yuling Liu1,2, Fangshun Tan1,2
1Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Current Pharmaceutical Design
|June 8, 2022
Summary
Long non-coding RNA MIR4435-2HG acts as an oncogene across numerous cancers, influencing tumor progression and patient prognosis. This review clarifies its role in various tumor types and potential as a diagnostic and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (LncRNAs) significantly impact tumor progression, driving extensive research.
- Several LncRNAs are implicated in promoting tumor growth, migration, and invasion across various cancers.
Purpose of the Study:
- To elucidate the pathophysiological functions of LncRNA MIR4435-2HG in multiple tumor types.
- To summarize the relationship between MIR4435-2HG and cancer development and its molecular mechanisms.
Main Methods:
- Literature search conducted through PubMed.
- Synthesis of existing research on MIR4435-2HG's role in cancer.
Main Results:
- MIR4435-2HG functions as an oncogene, with elevated expression observed in melanoma, gastric, lung, breast, and other cancers.
- High MIR4435-2HG levels correlate with poor prognosis and affect tumor proliferation, invasion, and apoptosis.
- MIR4435-2HG also influences the metabolic function of myeloid dendritic cells in HIV-1 controllers.
Conclusions:
- MIR4435-2HG plays a critical role in the development of diverse cancers.
- MIR4435-2HG shows potential as a clinical biomarker for early tumor detection and a target for cancer therapy.
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