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In Vivo Skin Colonization and Decolonization Models for Candida auris
Janet Herrada1, Ahmed Gamal1, Lisa Long1
1Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
Methods in Molecular Biology (Clifton, N.J.)
|June 8, 2022
Summary
Candida auris is a dangerous, multidrug-resistant yeast causing severe infections. This study details two animal models—guinea pig and mouse—for studying Candida auris pathogenesis and developing new treatments.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Drug Development
Background:
- Candida auris infections are a critical global health problem, causing disseminated, cutaneous, and wound infections.
- This yeast exhibits multidrug resistance, making eradication difficult.
- C. auris colonization of skin poses a significant infection risk.
Purpose of the Study:
- To describe two novel animal models for studying Candida auris.
- To facilitate research into C. auris pathogenesis.
- To aid in the development of new therapeutic strategies against C. auris.
Main Methods:
- Development of a cutaneous infection guinea pig model for C. auris.
- Establishment of a skin decolonization mouse model for C. auris.
Main Results:
- The described models provide valuable tools for investigating C. auris.
- These models are crucial for understanding infection mechanisms.
- The models support preclinical drug development for C. auris infections.
Conclusions:
- Animal models are essential for advancing our understanding of Candida auris.
- These specific models offer promising avenues for future research and therapeutic innovation.
- Effective management of C. auris requires continued research into its pathogenesis and treatment.
