Related Experiment Video
Updated: Sep 20, 2025
11:13
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
1.7K
HOXA1, a breast cancer oncogene
Magali Belpaire1, Arnaud Taminiau1, Dirk Geerts2
1Animal Molecular and Cellular Biology Group (AMCB), Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Louvain-la-Neuve, Belgium.
Biochimica Et Biophysica Acta. Reviews on Cancer
|June 8, 2022
Summary
HOXA1 is an oncogene driving breast cancer development. This review details its molecular mechanisms, expression regulation, and target genes, offering insights into breast cancer etiology and potential treatments.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- HOXA1 expression in human breast cancer was first noted over 25 years ago.
- HOXA1 has since been confirmed as an oncogene in mammary tissue.
- Extensive molecular data now exists on HOXA1's function and role in breast oncogenesis.
Purpose of the Study:
- To provide a comprehensive overview of molecular data concerning the HOXA1 oncoprotein.
- To explore HOXA1's expression modulators, interactors, and controlled pathways/genes.
- To elucidate the multi-modal oncogenic activities of HOXA1 in breast cancer.
Main Methods:
- Review of accumulated molecular data on HOXA1.
- Analysis of large-scale transcriptomic data from patient cohorts.
- Synthesis of information on HOX genes in cancer hallmarks.
Main Results:
- HOXA1 acts as a transcription factor involved in breast oncogenesis.
- Expression of HOXA1 is linked to specific breast cancer subtypes.
- HOXA1's oncogenic activities are multi-modal, involving various molecular interactions.
Conclusions:
- HOXA1 plays a significant role in breast cancer etiology.
- Understanding HOXA1's molecular biology enhances comprehension of breast cancer.
- This review provides a basis for exploring new therapeutic opportunities targeting HOXA1.
Related Concept Videos
01:33Cancer-Critical Genes I: Proto-oncogenes
9.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.2K
02:33Hedgehog Signaling Pathway
7.5K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.5K
01:06Induced Pluripotent Stem Cells
4.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.4K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.2K
02:53Adaptive Mechanisms in Cancer Cells
6.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K