Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral and brainstem auditory function in paroxysmal (px) White Leghorn chicks.

M M Beck, H M Brown-Borg, T A Jones

    Brain Research
    |March 17, 1987
    PubMed
    Summary

    The paroxysmal chick, a mutant chicken, develops anorexia and audiogenic seizures due to degeneration in auditory and vestibular systems. Brainstem auditory responses are abnormal, indicating neurological deficits in these mutant birds.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk of acute pulmonary embolism in COVID-19 pneumonia compared to community-acquired pneumonia: a retrospective case-control study.

    Clinical radiology·2021
    Same author

    Limestone particle size fed to pullets influences subsequent bone integrity of hens.

    Poultry science·2018
    Same author

    The somatotropic axis and longevity in mice.

    American journal of physiology. Endocrinology and metabolism·2015
    Same author

    Warfarin dosing after bariatric surgery: a retrospective study of 10 patients previously stable on chronic warfarin therapy.

    Clinical obesity·2015
    Same author

    The effect of stocking density in transit on the carcass quality and welfare of slaughter pigs: 1. Carcass measurements.

    Meat science·2011
    Same author

    Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor.

    Restorative neurology and neuroscience·2011

    Area of Science:

    • Neuroscience
    • Genetics
    • Avian Biology

    Background:

    • The paroxysmal (px) chick is a mutant White Leghorn exhibiting normal development initially.
    • By 8 days posthatching, px chicks display anorexia and audiogenic seizures.
    • Histological data indicate degeneration in central auditory and vestibular nuclei and tracts preceding seizure onset.

    Purpose of the Study:

    • To investigate the neurological basis of audiogenic seizures in the paroxysmal chick mutant.
    • To characterize auditory pathway function in px chicks compared to normal controls.

    Main Methods:

    • Auditory brainstem response (ABR) testing was performed on px and normal chicks.
    • Analysis focused on waveform peaks reflecting peripheral and brainstem auditory processing.

    Related Experiment Videos

  • Induced hypothermia was used to assess its effect on ABR in normal chicks.

    • Main Results:

    • Peripheral auditory structures (early ABR peaks P1A, P2A) functioned normally in px chicks.
    • Significant abnormalities were observed in later ABR peaks (P3A, P3B, P4A, P5A) in px chicks, including reduced amplitude, altered latency, and absence.
    • Induced hypothermia in normal chicks could not replicate the severe ABR abnormalities seen in px chicks.

    Conclusions:

    • The paroxysmal chick mutant exhibits specific deficits in central auditory processing, particularly at the brainstem level.
    • These neurological abnormalities correlate with the observed audiogenic seizures and anorexia.
    • The px chick serves as a valuable model for studying auditory pathway degeneration and seizure disorders.