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Conservative Management of Muscle Invasive Bladder Cancer in Kidney-Pancreas Transplant Patient
Logan D Glosser1, Brandon S Zakeri1, Conner V Lombardi1
1College of Medicine, University of Toledo College of Medicine and Life Sciences, USA.
Case Reports in Transplantation
|June 9, 2022
Summary
Muscle-invasive bladder cancer (MIBC) is a risk for transplant recipients. Trimodal therapy (TMT) offers a bladder-preserving option for these patients, showing no evidence of gross tumors at 3.5 years.
Area of Science:
- Urology
- Oncology
- Transplant Surgery
Background:
- Solid organ transplant recipients have an increased risk of developing muscle-invasive bladder cancer (MIBC).
- Urothelial cell carcinoma (UCC) in kidney-pancreas transplant recipients is rarely documented.
Observation:
- A 65-year-old male with a history of type 1 diabetes and a 14-year pancreas-kidney transplant presented with gross hematuria and multiple bladder masses.
- Initial transurethral resection of bladder tumor (TURBT) revealed papillary UCC; a later TURBT confirmed MIBC.
Findings:
- The patient opted for bladder-preserving trimodal therapy (TMT) instead of radical cystectomy.
- At 3.5 years post-diagnosis, cystoscopy revealed no gross evidence of recurrent carcinoma.
Implications:
- This case suggests TMT is a viable bladder-sparing treatment for MIBC in pancreas-kidney transplant patients.
- Adopting TMT may help preserve the function of transplanted allografts in this specific patient population.
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