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The Developing Human Connectome Project Neonatal Data Release.

A David Edwards1,2, Daniel Rueckert3,4, Stephen M Smith5

  • 1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Frontiers in Neuroscience
|June 9, 2022
PubMed
Summary
This summary is machine-generated.

The Developing Human Connectome Project offers open-access neonatal brain imaging data for studying typical and atypical neurodevelopment. This resource aids researchers investigating brain development from gestation through early infancy.

Keywords:
Developing Human Connectome ProjectMRIbrain developmentconnectomeneonatalperinatal

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • The Developing Human Connectome Project (dHCP) is an initiative to create a comprehensive open science resource.
  • Understanding typical and atypical brain development is crucial for early diagnosis and intervention.

Purpose of the Study:

  • To release a substantial dataset of neonatal magnetic resonance imaging (MRI) data.
  • To provide researchers with multimodal data for investigating perinatal brain development.
  • To detail the dHCP image acquisition and processing protocols.

Main Methods:

  • Acquisition of 1228 multimodal MRI brain datasets from 1173 fetal and/or neonatal participants.
  • Utilized specialized motion-tolerant imaging sequences on a single MRI scanner.
  • Collected extensive demographic, clinical, neurocognitive, and genomic data.

Main Results:

  • Release of 887 neonatal MRI datasets from 783 infants, including healthy, preterm, and high-risk neonates.
  • Data includes longitudinal imaging for some participants.
  • Comprehensive imaging and collateral data are now accessible.

Conclusions:

  • The dHCP provides a valuable, open-access resource for studying early brain development.
  • The released neonatal data facilitates research into neurodevelopmental trajectories.
  • Detailed protocols ensure data quality and reproducibility.