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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Sep 20, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Recurrent melanoma arising from sclera.

Hillary C Stiefel1, Audra Miller1, David J Wilson1

  • 1Oregon Health & Science University, Department of Ophthalmology (Casey Eye Institute), 3375 SW Terwilliger Blvd, Portland, OR, 97239, USA.

American Journal of Ophthalmology Case Reports
|June 9, 2022
PubMed
Summary
This summary is machine-generated.

This case study highlights recurrent malignant melanoma originating from intrascleral melanocytes. The tumor recurred 15 years after initial excision, emphasizing the need for long-term surveillance.

Keywords:
IridocyclectomyOcular melanomaRecurrent melanomaScleral melanoma

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Area of Science:

  • Ophthalmology
  • Oncology
  • Dermatology

Background:

  • Malignant melanoma can rarely arise from intrascleral melanocytes.
  • Intrascleral melanomas pose diagnostic and management challenges due to their location and potential for recurrence.

Observation:

  • A 46-year-old male presented with a subconjunctival malignant melanoma, presumed to originate from the sclera.
  • The initial tumor extended intraocularly and subconjunctivally, treated with en bloc removal and iridocyclectomy.
  • Fifteen years later, a recurrent pigmented limbal lesion was excised, consistent with melanoma.

Findings:

  • Histopathology confirmed recurrent malignant melanoma with atypical cells.
  • The recurrence occurred at the site of previous surgery, suggesting a persistent or de novo origin from intrascleral melanocytes.

Implications:

  • This case underscores the possibility of late recurrence of intrascleral malignant melanoma.
  • Long-term ophthalmologic follow-up is crucial for patients with a history of ocular melanoma.
  • Understanding the behavior of intrascleral melanomas can inform treatment strategies and improve patient outcomes.