Novel design of multifunctional nanozymes based on tumor microenvironment for diagnosis and therapy

Nanozymes have entranced considerable concern since they provide a likelihood strategy for performing the integration of diagnosis and therapy. Nanozymes, as emerging nanomaterials with enzyme-like activity, have been activated with tumor microenvironment (TME) endogenous stimulators. Compared with previous nanomaterials, nanozymes combined with multi-enzyme-like activities, multi-modal imaging methods, and multifunctional therapy platforms show tremendous advantages, conducting effective therapy. Given remarkable progress in emerging nanozymes for theranostics based on the TME, it is imperative to summarize the advancement of smart nanozymes responsive to various triggers including material composition, designed structure, response strategies, and excitation methods. Ultimately, the obstacles and difficulties in clinical applications of nanozymes based on the TME were reasonably discussed. It is anticipated that this review could offer meaningful information in this field.