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Related Experiment Video

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High-density single-unit human cortical recordings using the Neuropixels probe.

Jason E Chung1, Kristin K Sellers2, Matthew K Leonard2

  • 1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

Neuron
|June 9, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a reliable method for intraoperative human neural recordings using Neuropixels probes, enabling simultaneous recording of up to 100 neurons. This breakthrough offers unprecedented access to population single-unit activity in the human neocortex.

Keywords:
Neuropixelsextracellular recordinghuman electrophysiologyhuman intraoperative recordingsingle-unit recording

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Area of Science:

  • Neuroscience
  • Neural Engineering

Background:

  • Recording neural activity is crucial for understanding brain function.
  • Existing methods for large-scale neural recordings are limited in human subjects due to clinical constraints and electrode reliability.

Purpose of the Study:

  • To present a reliable method for intraoperative recording of dozens of neurons in humans.
  • To achieve high-yield, simultaneous single-unit recordings in the human neocortex.

Main Methods:

  • Utilized the Neuropixels probe for intraoperative neural recordings in human subjects.
  • Analyzed the correlation between electrode array motion and recording yield.
  • Examined the spatial proximity of simultaneously active cell pairs.

Main Results:

  • Successfully recorded up to approximately 100 simultaneously active single units.
  • Most recorded single units became active within one minute of reaching target depth.
  • Electrode array motion was inversely correlated with recording yield, highlighting a key challenge.
  • Simultaneously active cell pairs were often spatially proximate, enabling resolution of cortical dynamics.

Conclusions:

  • The Neuropixels probe provides a reliable method for high-density neural recordings in humans.
  • This approach offers unprecedented access to population single-unit activity across human neocortical depth.
  • Further improvements in minimizing electrode motion could significantly enhance probe utility.