Related Experiment Video

Updated: Sep 20, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

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Left Atrial Strain Has Superior Prognostic Value to Ventricular Function and Delayed-Enhancement in

Anne G Raafs1, Jacqueline L Vos2, Michiel T H M Henkens3

  • 1Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.

JACC. Cardiovascular Imaging
|June 9, 2022
PubMed

Insights

Left atrial conduit strain measured by cardiac magnetic resonance (CMR) is a powerful predictor of adverse outcomes in dilated cardiomyopathy (DCM). This finding improves risk stratification for patients with DCM.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • The left atrium (LA) is a sensitive indicator of left ventricular (LV) dysfunction.
  • The prognostic significance of LA function, specifically strain, assessed via cardiac magnetic resonance (CMR) in patients with dilated cardiomyopathy (DCM) is not well-established.

Purpose of the Study:

  • To investigate the prognostic value of CMR-derived LA strain in patients diagnosed with DCM.
  • To determine if LA strain can predict adverse cardiovascular events in DCM.

Main Methods:

  • A cohort of 488 DCM patients with available CMR imaging was analyzed.
  • The primary endpoint included sudden cardiac death, heart failure hospitalization, or life-threatening arrhythmias.
  • Cubic spline analysis was used for continuous variable dichotomization.

Main Results:

  • LA conduit strain, NYHA functional class >II, and late gadolinium enhancement (LGE) were independent predictors of the primary endpoint in multivariable analysis.
  • LA conduit strain demonstrated a stronger association with outcomes than LA reservoir strain.
  • Incorporating LA conduit strain into prediction models significantly enhanced their accuracy and reclassification capabilities.

Conclusions:

  • CMR-derived LA conduit strain is a robust, independent prognostic marker in DCM.
  • LA conduit strain offers superior prognostic information compared to LV GLS, LVEF, and LAVI.
  • Integrating LA conduit strain into clinical practice can improve risk stratification for DCM patients.
Abstract

Keywords:
cardiac MRIdilated cardiomyopathyfeature tracking strainleft atrial phasic functionprognosis

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