Recent Progress in the Selective Fluorinations of Some Functionalized Cycloalkenes.
Melinda Nonn1, Csaba Paizs2, Loránd Kiss3
1MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117, Budapest, Hungary.
Chemical Record (New York, N.Y.)
|June 9, 2022
Summary
Researchers developed selective methods for synthesizing organofluorine compounds. These new techniques create versatile, fluorinated small molecules with multiple chiral centers, valuable in pharmaceutical research.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Fluorine Chemistry
Background:
- Organofluorine compounds are increasingly vital in synthetic organic chemistry and pharmaceutical research.
- The synthesis of versatile, fluorinated small molecules is of significant interest.
- Novel synthetic strategies are needed to access complex fluorinated structures.
Purpose of the Study:
- To develop selective and stereocontrolled methods for constructing fluorine-containing small molecular entities.
- To explore the transformation of functionalized cycloalkenes for fluorination.
- To create valuable synthetic protocols for pharmacologically relevant fluorinated derivatives.
Main Methods:
- Utilized functionalized cycloalkenes as starting materials.
- Developed selective transformations across the ring olefin bond.
- Employed stereocontrolled synthetic strategies.
Main Results:
- Successfully synthesized various fluorine-containing small molecular entities.
- Achieved selective and stereocontrolled construction of fluorinated compounds.
- Demonstrated methods for accessing derivatives with multiple chiral centers.
Conclusions:
- The developed synthetic methodologies are effective for creating complex organofluorine compounds.
- These protocols offer valuable approaches for preparing pharmacologically interesting fluorinated molecules.
- The methods may be applicable to the synthesis of other classes of organic compounds.
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