Related Experiment Video
Updated: Sep 20, 2025
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
16.5K
Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators?
Rita Nogueira-Ferreira1, Fábio Sousa-Nunes2,3, Adelino Leite-Moreira2,4
1UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal. rmferreira@med.up.pt.
Summary
Inflammation is linked to cachexia, but targeted therapies aren't always effective. This review identifies key inflammatory markers like IL-6 and CRP for diagnosis and monitoring cancer and cardiac cachexia.
Area of Science:
- Biomedical research
- Clinical diagnostics
- Pathophysiology
Background:
- Inflammation is a known driver of cachexia in chronic diseases.
- Therapies targeting inflammation do not consistently reverse cachexia, prompting debate on inflammation's role.
Purpose of the Study:
- To investigate the contribution of inflammatory markers to cachexia pathogenesis and diagnosis.
- Focus on noncommunicable diseases: cancer and cardiovascular diseases.
Main Methods:
- Systematic literature review in PubMed using specific keywords for cachexia biomarkers.
- Screening of 744 retrieved studies, with 98 papers on circulating biomarkers selected.
Main Results:
- Interleukin-6 (IL-6) and C-reactive protein (CRP) are key inflammatory markers for cachexia, useful for monitoring therapy.
- Specific markers identified: BNP, renin, obestatin for cardiac cachexia; GDF-15, TGF-β1, VEGF-C for cancer cachexia.
- NF-κB and JAK/STAT pathways link inflammation to muscle wasting, though targeted therapies show variable efficacy.
Conclusions:
- This analysis provides insights into cachexia pathogenesis, aiding diagnosis and personalized therapy development.
- Future research should focus on understanding specific cachexia phenotypes for targeted interventions.
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