[Experimental study of the pathogenesis of dysentery]

It was shown that experimental dysentery could be produced against the background of various pathologic conditions of experimental animals (avitaminosis, concurrent diseases, etc). The studies in vivo and in vitro showed that intraepithelial parasitising of Shigella occurred in dysentery but did not play the leading role in the pathogenesis of the disease. Macrophages played a more important role, particularly in formation of the bacterial carrier state. In order to resolve some disputable problems of the pathogenesis of dysentery it is necessary to take into account the biological properties of the causative agent which change under the influence ov various effects, as well as the state of reponsiveness of the host.