Pheochromocytoma triggered by coronavirus disease 2019: a case report

Hoda Naghshineh1, Amirhossein Hasanpour2, Naghmeh Ziaei3

  • 1Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Ganjafroz Street, Babol, I. R. of Iran.

Abstract

Insights

This study presents a rare case where coronavirus disease 2019 (COVID-19) unusually manifested as pheochromocytoma, leading to myocarditis and cerebrovascular issues. Further investigation revealed thyroid medullary carcinoma and Multiple Endocrine Neoplasia type 2 syndrome in the patient.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Oncology

Background:

  • Coronavirus disease 2019 (COVID-19) presents with diverse and not fully understood effects on the human body.
  • Pheochromocytoma, a neuroendocrine tumor, can arise sporadically or as part of hereditary syndromes like Multiple Endocrine Neoplasia type 2 (MEN 2).

Observation:

  • A case report details an Iranian patient with COVID-19 exhibiting unusual pheochromocytoma manifestations.
  • These unusual presentations included myocarditis and cerebrovascular involvement.

Findings:

  • The study identified pheochromocytoma as an atypical manifestation of COVID-19.
  • Further diagnostic workup confirmed co-existing thyroid medullary carcinoma and MEN 2 syndrome.
  • Successful treatment led to the resolution of many of the patient's symptoms.

Implications:

  • This case highlights the complex interplay between COVID-19 infection and endocrine disorders.
  • It underscores the importance of considering unusual presentations in patients with COVID-19.
  • The findings suggest a potential link between severe viral infections and the unmasking or development of hereditary endocrine syndromes.

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