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Techniques to Induce and Quantify Cellular Senescence
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LINCing Senescence and Nuclear Envelope Changes.

Bakhita R M Meqbel1, Matilde Gomes2, Amr Omer3

  • 1College of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar.

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|June 10, 2022
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Summary
This summary is machine-generated.

The nuclear envelope (NE) is crucial for cell organization and survival. This review highlights how linker of nucleoskeleton and cytoskeleton (LINC) complex proteins, beyond their structural role, are vital in cellular senescence.

Keywords:
LINC complexNesprinsSUNnuclear envelopesenescence

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Gerontology

Background:

  • The nuclear envelope (NE) is central to cellular organization, signaling, and survival.
  • The NE undergoes significant alterations during senescence, a key cellular aging process.
  • Lamin B1, an NE protein, is downregulated in senescence and serves as a senescence marker.

Purpose of the Study:

  • To review the multifaceted roles of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins in cellular senescence.
  • To emphasize the importance of LINC complex proteins in processes beyond their structural function at the NE.
  • To highlight LINC complex proteins as key players in senescence-associated nuclear changes.

Main Methods:

  • Literature review focusing on NE proteins and senescence.
  • Analysis of studies investigating LINC complex proteins and their functions.
  • Synthesis of current research on LINC complex proteins in DNA repair, signaling, and nuclear shape.

Main Results:

  • LINC complexes physically connect the cytoplasm and nucleoplasm, integrating mechanical signals.
  • LINC complex proteins exist in various isoforms with nucleoplasmic and cytoplasmic roles.
  • These proteins are implicated in DNA repair, cell signaling, and nuclear shape regulation, all relevant to senescence.

Conclusions:

  • LINC complex proteins play critical, diverse roles in cellular senescence.
  • Their functions extend beyond structural support to encompass essential cellular processes affected by aging.
  • Understanding LINC complex proteins offers insights into senescence mechanisms and potential therapeutic targets.