Daratumumab Improves Bone Turnover in Relapsed/Refractory Multiple Myeloma; Phase 2 Study "REBUILD"
Evangelos Terpos1, Ioannis Ntanasis-Stathopoulos1, Efstathios Kastritis1
1Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Cancers
|June 10, 2022
Summary
Daratumumab treatment in multiple myeloma (MM) patients showed potential to improve bone turnover. While bone resorption markers did not significantly change, bone formation markers increased, suggesting a positive impact on bone health.
Area of Science:
- Hematology
- Oncology
- Bone Metabolism
Background:
- Multiple myeloma (MM) is a hematologic malignancy affecting bone health.
- Bone turnover markers in serum can indicate bone dynamics during MM treatment.
- Understanding the impact of novel therapies on bone remodeling is crucial.
Purpose of the Study:
- To evaluate the effect of daratumumab on bone remodeling in patients with relapsed/refractory MM.
- To assess changes in bone turnover biomarkers during daratumumab therapy.
Main Methods:
- Prospective, open-label, phase 2 study (REBUILD).
- Daratumumab administered per approved indication.
- Measured serum biomarkers of bone turnover (CTX, TRACP-5b, osteocalcin, bone-specific alkaline phosphatase, procollagen type-I N-pro-peptide, dickkopf-1, C-C motif ligand-3) at baseline and 4 months.
Main Results:
- Median changes in bone resorption markers (CTX, TRACP-5b) were not statistically significant.
- Bone formation markers (osteocalcin, bone-specific alkaline phosphatase, procollagen type-I N-pro-peptide) increased significantly.
- Dickkopf-1 and C-C motif ligand-3 levels decreased significantly, indicating reduced osteoblast inhibition.
Conclusions:
- Daratumumab therapy may positively influence bone turnover in MM patients.
- The drug appears to promote bone formation and reduce factors that inhibit osteoblasts.
- Further research is warranted to confirm these bone-related effects in MM treatment.
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