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Updated: Sep 20, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Cats and SARS-CoV-2: A Scoping Review.

Ramona Doliff¹, Pim Martens¹

¹University College Venlo, Maastricht University, Nassaustraat 36, 5911 BV Venlo, The Netherlands.

Animals : an Open Access Journal From MDPI

|June 10, 2022

Summary

Cats can get infected with the virus causing COVID-19 (SARS-CoV-2), but they appear to play a minor role in its spread. Current evidence suggests no widespread circulation of SARS-CoV-2 among domestic cats.

Keywords:

COVID-19 SARS-CoV-2 cats scoping review systematic literature review

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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

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Published on: January 9, 2019

Area of Science:

Veterinary Medicine
Infectious Diseases
Epidemiology

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, has demonstrated the susceptibility of various animal species.
Close human-cat contact necessitates understanding the role of domestic cats in SARS-CoV-2 transmission dynamics.

Purpose of the Study:

To conduct a scoping review of existing literature on SARS-CoV-2 in cats.
To identify key concepts, research types, and knowledge gaps concerning feline susceptibility and transmission.

Main Methods:

A systematic literature search was conducted across PubMed, Google Scholar, Scopus, medRxiv, and bioRxiv.
A two-step screening process identified 27 peer-reviewed articles, 8 scientific communications, and 2 pre-prints for inclusion.

Main Results:

Key themes included feline susceptibility, immunity, infection prevalence, clinical signs, and human-to-cat (reverse zoonotic) and cat-to-cat transmission.
Identified research gaps include a lack of large-scale studies, underrepresentation of stray/feral/shelter cats, and limited data on non-experimental cat-to-cat transmission.

Conclusions:

Cats are susceptible to SARS-CoV-2, with reverse zoonotic transmission from humans being documented.
Despite susceptibility, cats appear to play a limited role in SARS-CoV-2 spread, with no evidence of sustained circulation within cat populations currently available.