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Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

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Published on: February 15, 2019

Extracellular Vesicles in Corneal Fibrosis/Scarring.

Vincent Yeung¹, Nikolay Boychev¹, Wissam Farhat¹

¹Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.

International Journal of Molecular Sciences

|June 10, 2022

Summary

Extracellular vesicles (EVs) play key roles in cell communication and corneal scarring. This review explores their pathological and therapeutic functions in corneal fibrosis, offering insights into visual acuity restoration.

Keywords:

cell-cell communication cornea exosomes extracellular vesicles (EV)fibrosis microvesicles scarring therapeutic wound healing

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In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

Area of Science:

Ophthalmology
Cell Biology
Biomedical Science

Background:

Cell-microenvironment communication is vital for physiological and pathological processes.
Extracellular vesicles (EVs) modulate cell signaling and hold therapeutic potential.
Corneal transparency is crucial for vision; trauma can lead to scarring and vision loss.

Purpose of the Study:

To review the clinical relevance of corneal fibrosis and scarring.
To examine the role of corneal stromal cells in wound repair and haze formation.
To explore the characterization, subtypes, and roles of EVs in corneal scarring.

Main Methods:

Literature review focusing on extracellular vesicles and corneal biology.
Analysis of pathological mechanisms in corneal fibrosis.
Examination of therapeutic applications of EVs in corneal scarring.

Main Results:

Corneal stromal cell activation drives fibrosis and haze.
EVs are implicated in both the pathology and potential therapy of corneal scarring.
Understanding EV mechanisms is crucial for addressing vision impairment.

Conclusions:

Corneal fibrosis is a significant cause of vision impairment.
EVs represent a promising area for therapeutic intervention in corneal scarring.
Further research into EV biology can advance treatments for corneal diseases.