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Updated: Sep 20, 2025

In Vivo Two-Photon Microscopy of Single Nerve Endings in Skin

In Vivo Two-Photon Microscopy of Single Nerve Endings in Skin

Published on: August 24, 2014

Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve.

Samer Merchant¹, Stewart Yeoh², Mark A Mahan²

¹Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA.

Journal of Clinical Medicine

|June 10, 2022

Summary

This summary is machine-generated.

This study introduces intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) to measure nerve microcirculation and microstructure. The novel IVIM-DTI method shows promise for assessing peripheral nerve injury severity.

Keywords:

DTI IVIM MRI blood flow injury nerve nervous system perfusion

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Last Updated: Sep 20, 2025

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Area of Science:

Biomedical Engineering
Radiology
Neuroscience

Background:

Peripheral nerve injury presents a significant public health challenge.
Nerve perfusion is a crucial biomarker for injury severity and prognosis.
Current imaging methods may not fully capture nerve microcirculation and microstructure.

Purpose of the Study:

To apply a novel formalism combining IVIM and DTI to simultaneously characterize microcirculation and microstructure in the rat sciatic nerve.
To assess the feasibility and potential of IVIM-DTI for quantifying peripheral nerve perfusion.
To establish a new imaging biomarker for peripheral nerve injury.

Main Methods:

Development and application of a combined intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) technique.
In vivo imaging of the rat sciatic nerve.
Comparison of in vivo IVIM-DTI results with postmortem measurements.

Main Results:

The in vivo IVIM-DTI signal revealed a fast diffusion compartment attributed to microcirculation.
This fast compartment's mean diffusivity was significantly different from postmortem measurements (p < 0.01).
A slower compartment's mean diffusivity was comparable to postmortem nerve values, indicating successful characterization of both perfusion and microstructure.

Conclusions:

The IVIM-DTI methodology is feasible for simultaneous characterization of anisotropic microcirculation and microstructure in peripheral nerves.
This technique holds potential for quantifying nerve perfusion, aiding in the assessment of peripheral nerve injury.
Further technical improvements and investigations are warranted to fully realize the clinical utility of IVIM-DTI for peripheral nerve imaging.