Parity-Adjusted Term Neonatal Growth Chart Modifies Neonatal Morbidity and Mortality Risk Stratification
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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Roie Kofman1, Rivka Farkash2, Misgav Rottenstreich2
1Department of Internal Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, POB 12000, Jerusalem 91120, Israel.
Insights
Using parity-customized charts for birth weight identification significantly improves the detection of small for gestational age (SGA) neonates at higher risk for adverse outcomes. This approach enhances neonatal risk assessment for better clinical management.
Area of Science:
- Neonatology
- Perinatal Epidemiology
- Obstetrics
Background:
- Accurate identification of neonates who are small for gestational age (SGA) or large for gestational age (LGA) is crucial for predicting adverse outcomes.
- Standard population-based birth weight charts may not adequately account for individual maternal factors like parity, potentially leading to misclassification of neonatal size.
Purpose of the Study:
- To compare the effectiveness of parity-customized birth weight charts versus standard population-based charts in identifying neonatal risk.
- To assess the impact of these different charting methods on the identification of SGA and LGA infants and their associated morbidities.
Main Methods:
- An observational, retrospective cohort study analyzed 132,815 singleton, term neonates using electronic birth records (2006-2017).
- Neonates were classified as SGA, LGA, or appropriate for gestational age (AGA) using both population-based (POP) and parity-customized (CUST) models.
- Specific focus was on neonates identified differently by each model (SGA/LGA CUST/POP ONLY).
Main Results:
- The customized model identified 53% more SGA neonates (SGA-CUST ONLY), who exhibited significantly higher rates of morbidity and mortality (OR = 1.33).
- Neonates identified as LGA by the customized model but AGA by the population model (LGA-CUST ONLY) showed increased morbidity risk (OR = 1.36).
- Neonatal mortality was exclusively observed in the SGA and AGA groups.
Conclusions:
- Parity-customized birth weight charts are a simple yet effective tool for improving the identification of neonatal risk for morbidity and mortality.
- This method offers a better platform for risk stratification in term neonates compared to standard population-based charts.
Abstract:
Objective: To investigate the impact of parity-customized versus population-based birth weight charts on the identification of neonatal risk for adverse outcomes in small (SGA) or large for gestational age (LGA) infants compared to appropriate for gestational age (AGA) infants. Study design: Observational, retrospective, cohort study based on electronic medical birth records at a single center between 2006 and 2017. Neonates were categorized by birth weight (BW) as SGA, LGA, or AGA, with the 10th and 90th centiles as boundaries for AGA in a standard population-based model adjusted for gestational age and gender only (POP) and a customized model adjusted for gestational age, gender, and parity (CUST). Neonates defined as SGA or LGA by one standard and not overlapping the other, are SGA/LGA CUST/POP ONLY. Analyses used a reference group of BW between the 25th and 75th centile for the population. Results: Overall 132,815 singleton, live, term neonates born to mothers with uncomplicated pregnancies were included. The customized model identified 53% more neonates as SGA-CUST ONLY who had significantly higher rates of morbidity and mortality compared to the reference group (OR = 1.33 95% CI [1.16−1.53]; p < 0.0001). Neonates defined as LGA by the customized model (LGA-CUST) and AGA by the population-based model LGA-CUST ONLY had a significantly higher risk for morbidity compared to the reference (OR = 1.36 95% CI [1.09−1.71]; p = 0.007) or the LGA POP group. Neonatal mortality only occurred in the SGA and AGA groups. Conclusions: The application of a parity-customized only birth weight chart in a population of singleton, term neonates is a simple platform to better identify birth weight related neonatal risk for morbidity and mortality.
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