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Updated: Sep 20, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
Gulim K Mukusheva1, Aigerym R Zhasymbekova1, Roza B Seidakhmetova1
1Karaganda Buketov University, Karaganda 100024, Kazakhstan.
Abstract:
An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.
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