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J wave syndrome: Benign or malignant?

Alborz Sherafati1, Masoud Eslami2, Reza Mollazadeh2

  • 1Assistant Professor, Department of Cardiology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

ARYA Atherosclerosis
|June 10, 2022
PubMed

Insights

J wave syndrome, an electrical heart condition, involves early repolarization and can lead to sudden cardiac death or ventricular arrhythmias. Understanding its phenotypes, like Brugada syndrome, is crucial for diagnosis and treatment.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Genetics

Background:

  • J wave syndrome is an electrical heart disease characterized by pathological early repolarization.
  • It presents a spectrum from aborted sudden cardiac death due to ventricular arrhythmia (VA) in young patients to asymptomatic findings on electrocardiography.

Purpose of the Study:

  • To describe two patients with early repolarization and Brugada syndrome.
  • To comprehensively discuss the definition, epidemiology, genetics, cellular mechanisms, diagnosis, risk stratification, and therapeutic options for J wave syndrome.

Main Methods:

  • Case report of two patients presenting with early repolarization and Brugada syndrome.
  • Detailed review and discussion of existing literature on J wave syndrome and its phenotypes.

Main Results:

  • The study details the clinical presentation and diagnostic findings in the two presented cases.
  • A thorough overview of the current understanding of J wave syndrome, including its genetic basis and cellular mechanisms, is provided.

Conclusions:

  • J wave syndrome encompasses diverse clinical manifestations and genetic underpinnings.
  • Effective risk stratification and therapeutic strategies remain key challenges in managing this cardiac electrical disease.

Keywords:
Brugada SyndromeSudden Cardiac DeathVentricular Tachycardia

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