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The Rational Use of Complement Inhibitors in Kidney Diseases

Fadi Fakhouri1, Nora Schwotzer1, Déla Golshayan2

  • 1Service de Néphrologie et d'hypertension, Département de Médecine, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne, Lausanne, Switzerland.

Kidney International Reports
|June 10, 2022
PubMed

Insights

Complement inhibitors are revolutionizing nephrology, particularly for atypical hemolytic uremic syndrome (aHUS). This review explores their role in kidney diseases and guides rational therapeutic use.

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Complement inhibitors represent a major breakthrough in clinical nephrology.
  • Complement inhibition has transformed outcomes for atypical hemolytic uremic syndrome (aHUS), a complement-mediated disorder.
  • Emerging evidence suggests complement inhibitors hold promise for other kidney diseases involving complement activation.

Purpose of the Study:

  • To review current knowledge on complement activation and inhibition in kidney diseases.
  • To identify gaps in understanding regarding complement-mediated kidney disorders.
  • To provide guidance for the rational use of complement inhibitors in nephrology.

Main Methods:

  • Literature review of complement activation pathways in renal diseases.
  • Analysis of clinical trial data for complement inhibitors in nephrology.
  • Synthesis of expert opinion on therapeutic complement modulation strategies.

Main Results:

  • Complement inhibitors have significantly improved aHUS patient outcomes.
  • Several kidney diseases show potential benefit from complement inhibition.
  • The expanding use of complement inhibitors necessitates a rational approach to treatment.

Conclusions:

  • Complement inhibition is a pivotal advancement in treating severe kidney diseases like aHUS.
  • Further research is needed to fully elucidate the role of complement in various nephropathies.
  • A strategic approach to complement modulation is crucial for optimizing therapy in kidney diseases.

Keywords:
complementcomplement inhibitorsglomerular diseases

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