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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit

Niyaz Mohammadzadeh Honarvar1, Mahsa Samadi1, Marzieh Seyedi Chimeh1

  • 1Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

International Journal of Clinical Practice
|June 10, 2022
PubMed

Insights

Vitamin D supplementation did not improve oxidative stress biomarkers in children with ADHD. This 3-month trial found no significant benefits, suggesting further research is needed.

Area of Science:

  • Pediatric Nutrition
  • Biochemistry
  • Clinical Trials

Background:

  • Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Oxidative stress is implicated in the pathophysiology of ADHD.
  • Vitamin D deficiency is prevalent in children and may influence neurodevelopment and oxidative stress.

Purpose of the Study:

  • To investigate the effect of vitamin D3 supplementation on biomarkers of oxidative stress in children diagnosed with ADHD.
  • To assess changes in 25-hydroxyvitamin D (25(OH)D), paraxonase-1 activity (PON-1), Total Antioxidant Capacity (TAC), and 8-isoprostane levels.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial involving 75 children (aged 6-12) with ADHD.
  • Participants received either vitamin D3 (2000 IU) or a placebo daily for 3 months.
  • Blood samples were analyzed at baseline and post-intervention.

Main Results:

  • Vitamin D supplementation significantly increased circulating 25(OH)D levels compared to placebo.
  • No significant reduction in 8-isoprostane levels (a marker of oxidative stress) was observed in the vitamin D group.
  • Serum PON-1 and TAC levels decreased in both groups, with no statistically significant difference between groups.

Conclusions:

  • Three months of vitamin D3 supplementation did not demonstrate beneficial effects on oxidative stress biomarkers in children with ADHD.
  • Further research is warranted to explore the potential role of vitamin D in ADHD and its associated oxidative stress pathways.
Abstract

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