Related Experiment Video
Updated: Sep 20, 2025

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Intravenous chlorpromazine for acute paediatric migraine
Ruth Mc Löllgen1,2,3,4, Franz E Babl1,2,5, Mark T Mackay2,5,6
1Emergency Department, The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.
Objective:
In paediatric migraine, ibuprofen, acetaminophen and triptans are safe, effective therapies but there is scant paediatric data informing second-line emergency treatment.
Methods:
Retrospective cohort study of children diagnosed with migraine at a tertiary children's hospital ED.
Results:
There were 207 children with migraine over a 1 year period. 46% received simple oral analgesia. 25% intravenous chlorpromazine, of whom 45% received further analgesia.
Conclusions:
While intravenous chlorpromazine as second-line agent was mostly safe, it had unclear efficacy given the requirement for further treatment and hospital admissions.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Parenteral Anesthetics: Overview
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Skeletal Muscle Relaxants: Therapeutic Uses
Depolarizing Blockers: Pharmocokinetics

