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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Noninvasive Hemoglobin Measurement Reduce Invasive Procedures in Thalassemia Patients.

Yüksel Bıcılıoğlu1, Alkan Bal2, Fatma Demir Yenigürbüz3

  • 1Department of Pediatric Emergency Medicine, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.

Hemoglobin
|June 10, 2022
PubMed
Summary
This summary is machine-generated.

Noninvasive spectrophotometric hemoglobin (SpHb) offers moderate agreement with laboratory hemoglobin (LabHb) in thalassemia patients. This method shows potential for screening anemia and guiding transfusion decisions in stable patients.

Keywords:
Hemoglobin (Hb)noninvasivepediatricthalassemia

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Area of Science:

  • Hematology
  • Medical Devices
  • Diagnostic Technology

Background:

  • Thalassemia patients require frequent hemoglobin monitoring and transfusions.
  • Laboratory hemoglobin (LabHb) measurement involves invasive blood sampling.
  • Noninvasive spectrophotometric hemoglobin (SpHb) offers a potential alternative for hemoglobin assessment.

Purpose of the Study:

  • To evaluate the agreement between noninvasive SpHb and laboratory LabHb measurements.
  • To assess the usability of SpHb in guiding transfusion decisions for thalassemia patients.
  • To determine the accuracy of SpHb in identifying patients needing transfusions.

Main Methods:

  • Prospective study involving 110 children with thalassemia.
  • Simultaneous measurement of SpHb and LabHb (gold standard) from venous blood.
  • Statistical analysis included Cohen's kappa, Pearson correlation, Bland-Altman plots, and linear regression.

Main Results:

  • A moderate agreement (kappa = 0.370) and high correlation (r = 0.675) were found between SpHb and LabHb.
  • Mean bias between SpHb and LabHb was 0.3 g/dL.
  • SpHb demonstrated 92.2% sensitivity and 57.1% specificity for detecting Hb <10.0 g/dL.

Conclusions:

  • SpHb measurement shows acceptable agreement with LabHb in thalassemia patients.
  • SpHb can be a valuable tool for screening anemia in hemodynamically stable hemoglobinopathy patients.
  • SpHb may aid in transfusion decision-making when combined with clinical findings.