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Related Concept Videos

Polymers02:34

Polymers

37.5K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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Related Experiment Video

Updated: Sep 20, 2025

Shape Memory Polymers for Active Cell Culture
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Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

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Cell-Responsive Shape Memory Polymers.

Junjiang Chen1,2, Lauren E Hamilton1,2, Patrick T Mather3

  • 1BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.

ACS Biomaterials Science & Engineering
|June 10, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces the first biocompatible shape memory polymer (SMP) that responds to cellular activity. The smart material demonstrates shape recovery triggered by enzymes secreted from human cells, maintaining over 90% cell viability.

Keywords:
Pellethanecell-responsive polymerscytocompatibilitypoly(ε-caprolactone)shape-memory polymers

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cellular Engineering

Background:

  • Biocompatible shape memory polymers (SMPs) are smart materials responding to stimuli.
  • Existing SMPs are typically triggered by thermal or photothermal events.
  • SMPs responsive to cellular activity have not been demonstrated.

Purpose of the Study:

  • To develop and demonstrate an SMP triggered by enzymatic activity from human cells.
  • To build upon previous work on enzyme-responsive SMPs.
  • To investigate cell-responsive shape memory performance and cytocompatibility.

Main Methods:

  • Dual electrospinning of poly(ε-caprolactone) (PCL) and Pellethane to form a fiber mat.
  • Utilizing PCL as a lipase-labile shape-fixing component and Pellethane as a stable shape memory component.
  • Analyzing shape-memory functionality and cytocompatibility using thermal analysis, SEM, and HepG2 cell incubation.

Main Results:

  • Characterization of the shape-memory functionality of the dual electrospun fiber mat.
  • Demonstration of successful cell-responsive shape recovery triggered by HepG2 cells.
  • Achieved greater than 90% cell viability, indicating excellent cytocompatibility.

Conclusions:

  • This work presents the first cytocompatible SMP responding to a cellular trigger.
  • The developed material shows potential for applications in cell-based assays and regenerative medicine.
  • Enzymatic triggering of SMPs by cellular activity opens new avenues for smart biomaterials.