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Updated: Sep 20, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Electrochemical Synthesis of β-Functionalized Ketones via Ring-Opening of Cycloalkanols
Lulu Zhao1, Qiwen Zhong1, Jian Tian1
1State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Abstract:
The electrochemical deconstructive functionalization of cycloalkanols with nucleophiles has been studied, which allows functionalization to occur exclusively at the β-position of ketones. The substrate scope includes a wide range of cycloalkanols as well as diverse N, O, C, and P-centered nucleophiles, providing ready access to β-functionalized ketones as products. Mechanistic studies support the generation of α,β-unsaturated ketones as key intermediates followed by Michael addition with nucleophiles.
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