Related Experiment Video
Updated: Sep 20, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
The Use of Personalized Functional Medicine in the Management of Type 2 Diabetes: A Single-Center Retrospective
Background:
There is a subgroup of patients with type 2 diabetes (T2D) in whom traditional treatment does not work well. Traditional management of T2D does not address the autoimmune component seen in a subgroup of patients with T2D.
Primary Study Objective:
We sought to evaluate the effectiveness of using a personalized functional medicine (PFM) approach to managing T2D.
Methods/Design:
Patient files from 2010 to 2015 were culled for patients previously diagnosed with T2D and their deidentified data regarding medications and T2D biomarker test results were compiled. A total of 35 patients were contacted for permission to use their deidentified data for the purposes of this article. Of 35 patients, 11 provided written consent.
Setting:
All participants had entered a single, private, integrative medicine clinic based in Maryland, USA.
Participants:
The patient group consisted of 5 women and 6 men; age 50 to 77 years. Each patient was taking an antidiabetic medication and had reached a plateau in recovery, or wanted to reduce their medication intake. Allopathic physicians were retained by patients undergoing PFM treatment.
Intervention:
After a thorough intake history was completed, necessary specimens were collected for analysis. Once test results were reviewed to identify nutrient deficiencies, intestinal dysbiosis, hormone imbalances, chemical burden and food immune reactivities, a personalized plan was developed for each individual patient. Each patient was retested appropriately during treatment. Treatment lasted from 2 to 10 months based on the patients' goals.
Primary Outcome Measures:
The effectiveness of the PFM approach was measured by the reduction in medication needed to manage T2D and improvement in T2D biomarkers.
Results:
At the end of PFM treatment, 6 patients were completely off T2D-related medications, and 5 had their doses reduced by 50%. Diabetes biomarkers improved: glucose decreased by an average of 78.36 mg/dL and hemoglobin A1c (HbA1c) was lowered by an average of 2.71%.
Conclusion:
In individuals not well-managed using traditional protocols, the PFM approach should be considered as an adjunct therapy.
More Related Videos
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Related Concept Videos
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...