Sepsis protocols to reduce mortality in resource-restricted settings: A systematic review

Area of Science:

• Critical Care Medicine
• Global Health
• Evidence-Based Practice

Background:

• Sepsis management varies globally, leading to higher mortality in resource-restricted settings.
• Effective sepsis protocols are crucial for critically ill patients worldwide.

Purpose of the Study:

• To review sepsis protocol components and implementation in resource-limited settings.
• To assess protocol compliance, impact on length of stay, and mortality.
• To identify facilitators and barriers to sepsis protocol implementation.

Main Methods:

• Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.
• Quality appraisal using the Johns Hopkins Nursing Evidence-Based Practice model.

Main Results:

• Six studies utilized modified sepsis protocols in resource-restricted settings.
• Interventions included education and modified protocols (screening tool, intervention bundle).
• Protocol compliance increased with standardized protocols and education.
• Sepsis-related mortality decreased by 22.6% with partial protocol implementation.
• Lack of resources is the primary barrier to full protocol implementation.

Conclusions:

• Simplified sepsis protocols are vital for reducing mortality in resource-limited areas.
• Clinician training and modified protocols are essential for successful sepsis management.
• Addressing resource limitations is critical for effective sepsis protocol implementation.