A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples
Mohammad Mehmandoust1, Yasamin Khoshnavaz2, Fatemeh Karimi3
1Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey; Sakarya University, Biomaterials, Energy, Photocatalysis, Enzyme Technology, Nano & Advanced Materials, Additive Manufacturing, Environmental Applications, And Sustainability Research & Development Group (BIOENAMS R&D Group), 54187, Sakarya, Turkey.
Abstract:
In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0-13.5 μM with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement.
