Related Experiment Video
Updated: Sep 8, 2025
08:06
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
9.1K
Intermittent Fasting as Possible Treatment for Heart Failure
Salvador Garza-González1, Bianca Nieblas1, María M Solbes-Gochicoa1
1Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabolómica, Monterrey, Nuevo León, México.
Current Vascular Pharmacology
|June 13, 2022
Summary
Intermittent fasting (IF) shows promise in preventing and treating heart failure (HF) by promoting beneficial metabolic changes and utilizing ketone bodies (KBs). Further research is needed to fully understand IF
Area of Science:
- Cardiovascular Research
- Metabolic Health
- Nutritional Science
Background:
- Western diets contribute to obesity and comorbidities like heart failure (HF).
- Intermittent fasting (IF) is increasingly recognized for its protective effects against metabolic diseases.
- Evidence suggests IF may offer benefits for managing heart failure.
Purpose of the Study:
- To present evidence supporting the beneficial effects of IF on heart failure.
- To explore the molecular mechanisms underlying IF's cardioprotective actions.
- To highlight the role of liver ketone bodies (KBs) in IF's effects on HF.
Main Methods:
- Review of current scientific literature on intermittent fasting and heart failure.
- Discussion of molecular pathways involved in IF's metabolic and signaling effects.
- Analysis of the role of ketone bodies (KBs) as energy substrates and signaling molecules.
Main Results:
- IF induces a metabolic switch in the heart, increasing ketone body (KB) utilization.
- KBs act as signaling molecules influencing gene expression related to oxidative stress and metabolism.
- Key molecular factors like AMPK, FGF21, sirtuins, and Nrf2 are implicated in IF's benefits.
- IF may help maintain circadian rhythms crucial for cardiac function.
Conclusions:
- Intermittent fasting demonstrates potential as a preventive and therapeutic strategy for heart failure.
- Ketone bodies (KBs) play a significant role in mediating the cardioprotective effects of IF.
- Further research is essential to elucidate mechanisms and optimize IF protocols for HF management.
Related Concept Videos
01:22Heart Failure VI: Adjunct Therapies
27
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
27
01:30Heart Failure V: Medical Management
23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23
01:30Heart Failure VII: Nursing Interventions
139
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
139
01:24Metabolic States of the Body: Fasting and Starvation
1.7K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.7K
01:22Heart Failure Drugs: β-Blockers
434
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
434
01:27Heart Failure I: Introduction
49
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
49