Circulating Galectin-3 and Aldosterone for Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter...

Area of Science:

• Cardiology
• Biomarkers
• Electrophysiology

Background:

• Circulating galectin-3 (Gal-3) and aldosterone (ALD) are implicated in fibrosis and inflammation.
• Their role in predicting atrial fibrillation (AF) recurrence post-radiofrequency catheter ablation (RFCA) requires clarification.

Purpose of the Study:

• To evaluate galectin-3 (Gal-3) and aldosterone (ALD) as predictors of AF recurrence after RFCA.
• To assess the combined predictive value of baseline Gal-3 and ALD levels for AF recurrence.

Main Methods:

• 153 patients undergoing RFCA had baseline Gal-3 and ALD levels measured.
• Univariate and multivariate Cox regression analyses identified predictors of AF recurrence.
• Receiver operating characteristic (ROC) and Kaplan-Meier (K-M) curves assessed predictor efficacy.

Main Results:

• AF recurrence occurred in 35 (22.88%) patients.
• Higher preoperative Gal-3 and ALD levels were significantly associated with AF recurrence.
• The combination of Gal-3 and ALD demonstrated superior prediction accuracy (AUC 0.893) compared to individual markers.

Conclusions:

• Elevated baseline Gal-3 and ALD levels are independent predictors of AF recurrence after RFCA.
• The combined assessment of preoperative Gal-3 and ALD levels significantly enhances prediction accuracy for AF recurrence.