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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Three-year clinical outcomes of left atrial appendage occlusion with or without ablation: insight from the RECORD study.

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Association Between Triglyceride-Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage

Xiao-Hai Jiang1, Mei-Xiang Wang1, Run-Zhong Wang1

  • 1Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|April 24, 2025
PubMed
Summary

The triglyceride-glucose (TyG) index is linked to incomplete device endothelialization after left atrial appendage occlusion (LAAO). Higher TyG index values indicate an increased risk of delayed healing, offering a simple predictive biomarker.

Keywords:
atrial fibrillationdevice related thrombosisendothelializationleft atrial appendage occlusiontriglyceride‐glucose index

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Area of Science:

  • Cardiology
  • Biomarkers
  • Medical Devices

Background:

  • The triglyceride-glucose (TyG) index is a recognized marker for insulin resistance.
  • Insulin resistance is associated with cardiovascular diseases.
  • The relationship between the TyG index and endothelialization after left atrial appendage occlusion (LAAO) remains unexplored.

Purpose of the Study:

  • To investigate the association between the TyG index and incomplete device endothelialization (IDE) following LAAO.
  • To determine if the TyG index can predict the risk of IDE in patients undergoing LAAO.

Main Methods:

  • Retrospective analysis of 594 patients with non-valvular atrial fibrillation (NVAF) undergoing LAAO.
  • Patients were stratified into quartiles based on their TyG index.
  • Logistic regression and restricted cubic spline (RCS) models were used to assess the association between TyG index and IDE.

Main Results:

  • A higher TyG index was independently associated with an increased risk of IDE postprocedure.
  • Specifically, the highest two quartiles of the TyG index showed a significant association with IDE.
  • RCS modeling confirmed a linear relationship between the TyG index and IDE, consistent across subgroups.

Conclusions:

  • Elevated TyG index is a significant predictor of incomplete device endothelialization after LAAO.
  • The TyG index presents a simple and cost-effective biomarker for assessing IDE risk in patients undergoing LAAO.